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Molecular Genetics and Cell Biology

Membrane organization
and signaling



Richard Fehon

Molecular Genetics and Cell Biology,
Graduate Program in Cell and Molecular Biology,
Committee on Development, Regeneration, and Stem Cell Biology,
Committee on Genetics, Genomics and Systems Biology

B.S., Zoology,
Duke University, 1980
Ph.D., Zoology,
University of Washington, 1986

Contact Information
Address: 920 E. 58th Street
Chicago, IL 60637
Office: Room CLSC 901F
Phone: (773) 702-5694
Fax: (773) 702-3172
Lab: Room CLSC901
Phone: (773) 834-1067



Our interests center on the molecular mechanisms by which signal transduction pathways are organized into specialized membrane domains. In addition to their known role in organizing receptors and downstream effectors into functional signaling complexes, such organized complexes function to integrate signaling activities from multiple pathways and to segregate simultaneous but distinct functions of a single pathway.

We study this question in Drosophila because of the utility of this system for studying functional interactions between different genes (and the proteins they encode) that work together in a particular cellular or developmental process. Our current studies focus primarily on the Hippo tissue growth control pathway, a highly conserved signaling mechanism that senses mechanical tension to ensure uniform growth in developing tissues.


  Research Projects:


Septate Junctions

A central problem in the development and function of epithelial cells is the process by which specialized membrane domains are formed and maintained. (more...)



Tissue Growth Control  

go to: proliferation control

The precise coordination of proliferation, apoptosis and nutrient acquisition is a key feature of growth regulation in developing tissues. (more...)



Epithelial Integrity  

Two prominent characteristics of epithelial cells, apical-basal polarity and a highly ordered cytoskeleton, depend on the existence of precisely localized protein complexes associated with the apical plasma membrane... (more...)

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