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Molecular Genetics and Cell Biology



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Optical section of the Drosophila wing epithelium stained for actin (red) and Coracle (green) a component of the septate junction.

 

 

Optical section of a fold in the Drosophila wing epithelium stained for Moesin (red, apical membrane), E-cadherin (blue, adherens junctions) and Coracle (green, septate junctions).

 

 

Wing imaginal disc from a Moesin mutant larva showing E-cadherin (blue), nuclei (red) and filamentous actin (green).

 

 

 

Drosophila ovariole stained for Merlin (red) and Moesin (green).

 

 

Pupal eye from Drosophila stained with antibodies for the Notch protein.

 

 

Drosophila larval salivary gland, a monolayered epithelial tube, expressing Merlin-GFP (green) and stained with propidium iodide (nuclei; red).

 

 

 

Adult Drosophila eyes carrying either control (white patch in left panel) or Merlin mutant (white patch in right panel) cell induced by mitotic recombination. Merlin mutant cells overproliferate relative to their neighbors (compare size of white patch to the control dark red patch).

 

 

Scanning electron micrographs of the compound eye from an EGFR[Elp] mutant animal (left panel) and an EGFR[Elp] animal that has reduced Coracle function.

 

 

A clone of wing imaginal disc cells (green) expressing dominant-negative Moesin crawling over the surface of the epithelium (epithelial marker red).

 

 

 

Drosophila embryo (dorsal closure stage) stained with an anti-Coracle antibody.

 

 

Drosophila Cdc42 mutant embryo, stained for Coracle (green), the peripheral nervous system (22C10, blue) and the central nervous system (anti-HRP, red).

 

 

 

 

 

Fehon RG, Dawson IA, Artavanis-Tsakonas S. A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. Development. 1994 Mar;120(3):545-57. (PubMed)

 

 

McCartney BM, Fehon RG. Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin. J Cell Biol. 1996 May;133(4):843-52. (PubMed)

 

 

LaJeunesse DR, McCartney BM, Fehon RG. Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization. J Cell Biol. 1998 Jun 29;141(7):1589-99. (PubMed)

 

 

 

Speck O, Hughes SC, Noren NK, Kulikauskas RM, Fehon RG. Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity. Nature. 2003 Jan 2;421(6918):83-7. (PubMed)

 

 

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Genova JL, Fehon RG. Neuroglian, Gliotactin, and the Na+/K+ ATPase are essential for septatejunction function in Drosophila. J Cell Biol. 2003 Jun 9;161(5):979-89. (PubMed)

 

 

 

 
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