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Molecular Genetics and Cell Biology

Membrane organization
and signaling

   

 

Richard Fehon



Professor and Chair,
Molecular Genetics and Cell Biology,
Graduate Program in Cell and Molecular Biology,
Committee on Cancer Biology,
Committee on Development, Regeneration, and Stem Cell Biology,
Committee on Genetics, Genomics and Systems Biology

B.S., Zoology,
Duke University, 1980
Ph.D., Zoology,
University of Washington, 1986


Contact Information
Address: 920 E. 58th Street
Chicago, IL 60637
Office: Room CLSC 925B
Phone: (773) 702-5694
Fax: (773) 702-3172
Lab: Room CLSC901
Phone: (773) 834-1067
E-Mail:

 
 

 

Our interests center on the molecular mechanisms by which signal transduction pathways are organized into specialized membrane domains. In addition to their known role in organizing receptors and downstream effectors into functional signaling complexes, such organized complexes function to integrate signaling activities from multiple pathways and to segregate simultaneous but distinct functions of a single pathway.

We study this question in Drosophila because of the utility of this system for studying the functions of individual genes via mutagenesis, and for examining the functional interactions between different genes that work together in a particular cellular or developmental process.

 

  Research Projects:

 

Septate Junctions

A central problem in the development and function of epithelial cells is the process by which specialized membrane domains are formed and maintained. (more...)

 

 

Proliferation Control  

go to: proliferation control

The precise coordination of signals that control proliferation is a key feature of growth regulation in developing tissues. (more...)

 

 

Epithelial Integrity  

Two prominent characteristics of epithelial cells, apical-basal polarity and a highly ordered cytoskeleton, depend on the existence of precisely localized protein complexes associated with the apical plasma membrane... (more...)

 
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