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| Molecular Genetics and
Cell Biology Membrane organization |
Richard Fehon
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Our interests center on the molecular mechanisms by which signal transduction pathways are organized into specialized membrane domains. In addition to their known role in organizing receptors and downstream effectors into functional signaling complexes, such organized complexes function to integrate signaling activities from multiple pathways and to segregate simultaneous but distinct functions of a single pathway. We study this question in Drosophila because of the utility of this system for studying the functions of individual genes via mutagenesis, and for examining the functional interactions between different genes that work together in a particular cellular or developmental process.
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| Research
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A central problem in the development and function of epithelial cells is the process by which specialized membrane domains are formed and maintained. (more...) |
The precise coordination of signals that control proliferation is a key feature of growth regulation in developing tissues. (more...) |
Two prominent characteristics of epithelial cells, apical-basal polarity and a highly ordered cytoskeleton, depend on the existence of precisely localized protein complexes associated with the apical plasma membrane... (more...) |
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